Slavé Petrovski
As the Vice President of AstraZeneca’s Centre for Genomics Research, I am dedicated to advancing genomics research with the aim to discover and develop some of the most advanced, novel and groundbreaking medicines for patients. My expertise spans population genetics, multi-omics, machine learning, and precision medicine, driving breakthroughs in target discovery and validation across disease areas. My work at AstraZeneca has led to the progression of numerous novel drug targets, reinforcing our commitment to improving patient outcomes through scientific innovation.
Since joining AstraZeneca in August 2017, I have played a pivotal role in designing and implementing numerous large-scale genomic studies. I am particularly passionate about enhancing AstraZeneca’s global collaboration network with academic, industry, government, and non-profit organizations to maximise our collective efforts and enhance our genomic diversity commitment. This is a vital part of the AstraZeneca Genomics Initiative, which aims to analyze two million genomes by 2026.
Today, our Centre for Genomics Research is a unified and centralised multi-omics and target-indication discovery unit within AstraZeneca. Working in close partnership across therapy areas, the CGR comprises four core functions in genomic sciences: Human Genetics (AstraZeneca’s Genomics Initiative), Dynamic Omics, Functional Genomics, and Translational Genomics. In partnership with Therapy Area colleagues, the Centre’s patient-centric focus supports the development of robust therapeutic strategies anchored in causal human biology.
We are at the forefront of integrating human genetics into drug discovery, significantly increasing the likelihood of successfully developing novel, innovative and effective medicines.
2023
2020
CURRENT ROLE
2023
2022
2021
Featured publications
Disease prediction with multi-omics and biomarkers empowers case–control genetic discoveries in the UK Biobank
Manik Garg, Marcin Karpinski, Dorota Matelska, Lawrence Middleton, Oliver S. Burren, Fengyuan Hu, Eleanor Wheeler, Katherine R. Smith, Margarete A. Fabre, Jonathan Mitchell, Amanda O’Neill, Euan A. Ashley, Andrew R. Harper, Quanli Wang, Ryan S. Dhindsa, Slavé Petrovski & Dimitrios Vitsios
Genetic architecture of telomere length in 462,666 UK Biobank whole-genome sequences
Oliver S. Burren, Ryan S. Dhindsa, Sri V. V. Deevi, Sean Wen, Abhishek Nag, Jonathan Mitchell, Fengyuan Hu, Douglas P. Loesch, Katherine R. Smith, Neetu Razdan, Henric Olsson, Adam Platt, Dimitrios Vitsios, Qiang Wu, AstraZeneca Genomics Initiative, Veryan Codd, Christopher P. Nelson, Nilesh J. Samani, Ruth E. March, Sebastian Wasilewski, Keren Carss, Margarete Fabre, Quanli Wang, Menelas N. Pangalos & Slavé Petrovski
Genotyping, sequencing and analysis of 140,000 adults from Mexico City
Andrey Ziyatdinov, Jason Torres, Jesús Alegre-Díaz, Joshua Backman, Joelle Mbatchou, Michael Turner, Sheila M. Gaynor, Tyler Joseph, Yuxin Zou, Daren Liu, Rachel Wade, Jeffrey Staples, Razvan Panea, Alex Popov, Xiaodong Bai, Suganthi Balasubramanian, Lukas Habegger, Rouel Lanche, Alex Lopez, Evan Maxwell, Marcus Jones, Humberto García-Ortiz, Raul Ramirez-Reyes, Rogelio Santacruz-Benítez, Abhishek Nag, Katherine R. Smith, Amy Damask, Nan Lin, Charles Paulding, Mark Reppell, Sebastian Zöllner, Eric Jorgenson, William Salerno, Slavé Petrovski, John Overton, Jeffrey Reid, Timothy A. Thornton, Gonçalo Abecasis, Jaime Berumen, Lorena Orozco-Orozco, Rory Collins, Regeneron Genetics Center, Mexico City Prospective Study, Aris Baras, Michael R. Hill, Jonathan R. Emberson, Jonathan Marchini, Pablo Kuri-Morales & Roberto Tapia-Conyer
Plasma proteomic associations with genetics and health in the UK Biobank
Benjamin B. Sun, Joshua Chiou, Matthew Traylor, Christian Benner, Yi-Hsiang Hsu, Tom G. Richardson, Praveen Surendran, Anubha Mahajan, Chloe Robins, Steven G. Vasquez-Grinnell, Liping Hou, Erika M. Kvikstad, Oliver S. Burren, Jonathan Davitte, Kyle L. Ferber, Christopher E. Gillies, Åsa K. Hedman, Sile Hu, Tinchi Lin, Rajesh Mikkilineni, Rion K. Pendergrass, Corran Pickering, Bram Prins, Denis Baird, Chia-Yen Chen, Lucas D. Ward, Aimee M. Deaton, Samantha Welsh, Carissa M. Willis, Nick Lehner, Matthias Arnold, Maria A. Wörheide, Karsten Suhre, Gabi Kastenmüller, Anurag Sethi, Madeleine Cule, Anil Raj, Alnylam Human Genetics, AstraZeneca Genomics Initiative, Biogen Biobank Team, Bristol Myers Squibb, Genentech Human Genetics, GlaxoSmithKline Genomic Sciences, Pfizer Integrative Biology, Population Analytics of Janssen Data Sciences, Regeneron Genetics Center, Lucy Burkitt-Gray, Eugene Melamud, Mary Helen Black, Eric B. Fauman, Joanna M. M. Howson, Hyun Min Kang, Mark I. McCarthy, Paul Nioi, Slavé Petrovski, Robert A. Scott, Erin N. Smith, Sándor Szalma, Dawn M. Waterworth, Lyndon J. Mitnaul, Joseph D. Szustakowski, Bradford W. Gibson, Melissa R. Miller & Christopher D. Whelan
FinnGen provides genetic insights from a well-phenotyped isolated population
Mitja I. Kurki, Juha Karjalainen, Priit Palta, Timo P. Sipilä, Kati Kristiansson, Kati M. Donner, Mary P. Reeve, Hannele Laivuori, Mervi Aavikko, Mari A. Kaunisto, Anu Loukola, Elisa Lahtela, Hannele Mattsson, Päivi Laiho, Pietro Della Briotta Parolo, Arto A. Lehisto, Masahiro Kanai, Nina Mars, Joel Rämö, Tuomo Kiiskinen, Henrike O. Heyne, Kumar Veerapen, Sina Rüeger, Susanna Lemmelä, Wei Zhou, Sanni Ruotsalainen, Kalle Pärn, Tero Hiekkalinna, Sami Koskelainen, Teemu Paajanen, Vincent Llorens, Javier Gracia-Tabuenca, Harri Siirtola, Kadri Reis, Abdelrahman G. Elnahas, Benjamin Sun, Christopher N. Foley, Katriina Aalto-Setälä, Kaur Alasoo, Mikko Arvas, Kirsi Auro, Shameek Biswas, Argyro Bizaki-Vallaskangas, Olli Carpen, Chia-Yen Chen, Oluwaseun A. Dada, Zhihao Ding, Margaret G. Ehm, Kari Eklund, Martti Färkkilä, Hilary Finucane, Andrea Ganna, Awaisa Ghazal, Robert R. Graham, Eric M. Green, Antti Hakanen, Marco Hautalahti, Åsa K. Hedman, Mikko Hiltunen, Reetta Hinttala, Iiris Hovatta, Xinli Hu, Adriana Huertas-Vazquez, Laura Huilaja, Julie Hunkapiller, Howard Jacob, Jan-Nygaard Jensen, Heikki Joensuu, Sally John, Valtteri Julkunen, Marc Jung, Juhani Junttila, Kai Kaarniranta, Mika Kähönen, Risto Kajanne, Lila Kallio, Reetta Kälviäinen, Jaakko Kaprio, FinnGen, Nurlan Kerimov, Johannes Kettunen, Elina Kilpeläinen, Terhi Kilpi, Katherine Klinger, Veli-Matti Kosma, Teijo Kuopio, Venla Kurra, Triin Laisk, Jari Laukkanen, Nathan Lawless, Aoxing Liu, Simonne Longerich, Reedik Mägi, Johanna Mäkelä, Antti Mäkitie, Anders Malarstig, Arto Mannermaa, Joseph Maranville, Athena Matakidou, Tuomo Meretoja, Sahar V. Mozaffari, Mari E. K. Niemi, Marianna Niemi, Teemu Niiranen, Christopher J. O´Donnell, Ma´en Obeidat, George Okafo, Hanna M. Ollila, Antti Palomäki, Tuula Palotie, Jukka Partanen, Dirk S. Paul, Margit Pelkonen, Rion K. Pendergrass, Slavé Petrovski, Anne Pitkäranta, Adam Platt, David Pulford, Eero Punkka, Pirkko Pussinen, Neha Raghavan, Fedik Rahimov, Deepak Rajpal, Nicole A. Renaud, Bridget Riley-Gillis, Rodosthenis Rodosthenous, Elmo Saarentaus, Aino Salminen, Eveliina Salminen, Veikko Salomaa, Johanna Schleutker, Raisa Serpi, Huei-yi Shen, Richard Siegel, Kaisa Silander, Sanna Siltanen, Sirpa Soini, Hilkka Soininen, Jae Hoon Sul, Ioanna Tachmazidou, Kaisa Tasanen, Pentti Tienari, Sanna Toppila-Salmi, Taru Tukiainen, Tiinamaija Tuomi, Joni A. Turunen, Jacob C. Ulirsch, Felix Vaura, Petri Virolainen, Jeffrey Waring, Dawn Waterworth, Robert Yang, Mari Nelis, Anu Reigo, Andres Metspalu, Lili Milani, Tõnu Esko, Caroline Fox, Aki S. Havulinna, Markus Perola, Samuli Ripatti, Anu Jalanko, Tarja Laitinen, Tomi P. Mäkelä, Robert Plenge, Mark McCarthy, Heiko Runz, Mark J. Daly & Aarno Palotie
Genome-wide analyses of 200,453 individuals yield new insights into the causes and consequences of clonal hematopoiesis
Siddhartha P. Kar, Pedro M. Quiros, Muxin Gu, Tao Jiang, Jonathan Mitchell, Ryan Langdon, Vivek Iyer, Clea Barcena, M. S. Vijayabaskar, Margarete A. Fabre, Paul Carter, Slavé Petrovski, Stephen Burgess & George S. Vassiliou
Human genetics uncovers MAP3K15 as an obesity-independent therapeutic target for diabetes
Abhishek Nag, Ryan S. Dhindsa, Jonathan Mitchell, Chirag Vasavda, Andrew R. Harper, Dimitrios Vitsios, Andrea Ahnmark, Bilada Bilican, Katja Madeyski-Bengtson, Bader Zarrouki, Anthony W. Zoghbi, Quanli Wang, Katherine R. Smith, Jesus Alegre-Díaz, Pablo Kuri-Morales, Jaime Berumen, Roberto Tapia-Conyer, Jonathan Emberson, Jason M. Torres, Rory Collins, David M. Smith, Benjamin Challis, Dirk S. Paul, Mohammad Bohlooly-Y, Mike Snowden, David Baker, Regina Fritsche-Danielson, Menelas N. Pangalos, and Slavé Petrovski
Rare and Common Variants in KIF15 Contribute to Genetic Risk of Idiopathic Pulmonary Fibrosis
David Zhang, Gundula Povysil, Philippe H. Kobeissy, Qi Li, Binhan Wang, Mason Amelotte, Hager Jaouadi, Chad A. Newton, Toby M. Maher, Philip L. Molyneaux, Imre Noth, Fernando J. Martinez, Ganesh Raghu, Jamie L. Todd, Scott M. Palmer, Carolina Haefliger, Adam Platt, Slavé Petrovski, Joseph A. Garcia, David B. Goldstein and Christine Kim Garcia
Rare variant contribution to human disease in 281,104 UK Biobank exomes
Quanli Wang, Ryan S. Dhindsa, Keren Carss, Andrew R. Harper, Abhishek Nag, Ioanna Tachmazidou, Dimitrios Vitsios, Sri V. V. Deevi, Alex Mackay, Daniel Muthas, Michael Hühn, Susan Monkley, Henric Olsson, AstraZeneca Genomics Initiative, Sebastian Wasilewski, Katherine R. Smith, Ruth March, Adam Platt, Carolina Haefliger & Slavé Petrovski
Advancing human genetics research and drug discovery through exome sequencing of the UK Biobank
Joseph D. Szustakowski, Suganthi Balasubramanian, Erika Kvikstad, Shareef Khalid, Paola G. Bronson, Ariella Sasson, Emily Wong, Daren Liu, J. Wade Davis, Carolina Haefliger, A. Katrina Loomis, Rajesh Mikkilineni, Hyun Ji Noh, Samir Wadhawan, Xiaodong Bai, Alicia Hawes, Olga Krasheninina, Ricardo Ulloa, Alex E. Lopez, Erin N. Smith, Jeffrey F. Waring, Christopher D. Whelan, Ellen A. Tsai, John D. Overton, William J. Salerno, Howard Jacob, Sandor Szalma, Heiko Runz, Gregory Hinkle, Paul Nioi, Slavé Petrovski, Melissa R. Miller, Aris Baras, Lyndon J. Mitnaul, Jeffrey G. Reid & UKB-ESC Research Team
Veeva ID: Z4-72188
Date of preparation: February 2025